Are You Feeling Depressed?

45% of Australians experience a mental health condition in their lifetime.  In any one year, around 1 million Australian adults have depression, and over 2 million have anxiety.

How do I know if I am depressed?

  • Not going out anymore
  • Not getting things done at work/school
  • Withdrawing from close family and friends
  • Relying on alcohol and sedatives
  • Not doing usual enjoyable activities
  • Unable to concentrate

  • Overwhelmed
  • Guilty
  • Irritable
  • Frustrated
  • Unhappy
  • Miserable
  • Sad
  • Indecisive
  • Disappointed
  • Lacking in confidence
  • “I’m a failure.”
  • “It’s my fault.”
  • “Nothing good ever happens to me.”
  • “People would be better off without me.”
  • “Life’s not worth living.”
  • “I’m worthless.”
  • Tired all the time
  • Sick and run down
  • Churning gut
  • Sleep problems
  • Loss or change of appetite
  • Significant weight loss or gain
  • Headaches and muscle pains

The Gut-Brain Axis

The Missing Link in Depression

The gut microbiota is essential to human health and the immune system and plays a major role in the bidirectional communication between the gut and the brain. Based on evidence, the gut microbiota is associated with metabolic disorders such as obesity, diabetes mellitus and neuropsychiatric disorders such as schizophrenia, autistic disorders, anxiety disorders and major depressive disorders. In the past few years, neuroscientific research has shown the importance of the microbiota in the development of brain systems. Recent studies showed that the microbiota could activate the immune and central nervous systems, including commensal and pathogenic microorganisms in the gastrointestinal tract.Gut microorganisms are capable of producing and delivering neuroactive substances such as serotonin and gamma-aminobutyric acid, which act on the gut-brain axis. Preclinical research in rodents suggested that certain probiotics have antidepressant and anxiolytic activities.Effects may be mediated via the immune system or neuroendocrine systems. Clin Psychopharmacol Neurosci. 2015 Dec: 13(3): 239-244 Published online 2015 Dec 31. doi: 10.9758/cpn.2015. 13.3.239 PMCID: PMC4662178



Why rectally & not orally?

The large intestine ‘colon’ has the most microbial colonisation in the digestive tract, 100 Billion cfu/ml. Probiotics taken orally need to survive the acidic environment of our stomach. The pH of the stomach is 1.0 -3.0. The pH of the colon is 5.5-7.5 (1,2,3). Probiotics taken rectally bypass the acidic environment in the stomach, and the travelling distance of 7.5m approximately to the colon. Probiotics taken rectally ensures the destination is reached and the bacteria are still alive and stable.

  1. S Biradar, S Bahagvati, B Sheunshi. Probiotics And Antibiotics: A Brief Overview. The Internet Journal of Nutrition and Wellness.  2004 Volume 2 Number 1
  2. M Blaut, T Clavel, 2007; Nugent SG et al, 2001
  3. J Gerritsen, H Smidt, G Rijkers, W de Vos. Intestinal microbiota in human health and disease: the impact of probiotics. Genes Nutr. 2011 Aug; 6(3): 209-240. Published online 2011 May 27. doi: 10.1007/s12263-011-0229-7

How can 360 Health help you?

  1. Cleanse the bad bacteria out of your colon.
  2. Alkaline your colon so the pH is ideal for good bacteria to colonise.
  3. Deliver the probiotic rectally bypassing the acidic environment of the stomach and 7.5m of travel to the colon.
  4. Ensure delivery to the destination with live and stable bacteria which may increase the natural production of serotonin, the body’s happy chemical, thus reducing depression.  It has been estimated that about 95% of serotonin is found in the Gastro Intestinal tract (4).
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